ENROCOLIN
antibiotic oral solution
Composition
100 ml of preparation contains active substances: Enrofloxacin – 10.0 g,
Colistin sulphate — 100 000 000 IU;
Additional ingredients.
Pharmacological properties
Enrocolin is a complex preparation; its therapeutic effect is caused by a synergistic effect of active ingredients of the product: Enrofloxacin and Colistin sulphate.
Enrofloxacin belongs to the group of fluoroquinolones, it inhibits synthesis of DNA in nucleus of cells of microorganisms. The product has bactericidal action against Gram- positi e and Gram-negative microorganisms (Staphylococcus aureus, Enterobacteriaceae, Pas- teurella spp., Haemophilus spp., Acti spp., Brucella spp., Bordetella bronchisepti a, Pseudomonas aeruginosa, Salmonella spp., Pasteurella spp., etc.), as well as against mycoplasmas (Mycoplasma spp.) and chlamydia (Chlamydia spp.).
Colisti is an antibioti of the group of polymyxins, which are synthesized by aerobic spore- forming coli Bacillus polymyxa. Colisti as part of the formulati has bactericidal effect on Gram-negative bacteria (E. coli, Salmonella spp., Pasteurella spp., Haemophilus spp., Bordetella spp.). Colisti binds to phospholipids of the cytoplasmic membrane, enhances its permeability for intra and external cell components, which leads to destructi of bacterial cell.
The product is rapidly absorbed and penetrates into all tissues and organs of the body. Mmaximum concentration of preparation in the blood is achieved in 2 hours after application and lasts for 3-4 hours, therapeutic concentration lasts for 24 hours. Excreted in the urine, bile and feces.
Administration
Treatment of small ruminants, calves before 3 month of age, swine and poultry with respi- ratory and digestive tract diseases caused by microorganisms susceptible to Enrofloxacin and Colistin.
Main indications for use:
- chronic respiratory disease (Mycoplasma gallisepticum, E. Coli);< >infectious synovitis (Mycoplasma synoviae);
- aerosoculitis (M. meleagridis);
- colibacillosis (E. Coli);
- salmonellosis (Salmonella spp.);
- pasteurellosis (Pasteurella multocida);
- turkey bordetellosis (Bordetella avium);
- erysipelas (Erysipelothrix rhusiopathiae);
- staphylococcosis (Staphylococcus aureus);
- chlamydiosis (Chlamydia psittaci).
Routes of administration and dosages
|
Animal species |
Indications |
Dosage |
Duration of treatment |
Routes of administration |
|
Calves under 3 months of age, pigs |
Normal course of resp. & gastro-intestinal disease |
0.3 ml/kg body weight |
3-5 days |
Orally with drinking water |
|
Severe form of the disease |
0.5 ml/kg body weight |
|||
|
Domestic poultry (chickens, broilers, turkeys) |
Broiler and parent chicks, turkeys before 3 month; layer chicks before 5 month age |
0.5-1.0 ml/L drinking water |
||
|
Broiler and parent chicks, turkeys after 3 month; layer chicks after 5 month age |
1.0 ml/L drinking water |
In case of Salmonellosis, mixed bacterial infections, chronic diseases of poultry: treatment should last for 5-7 days.
During treatment, the birds should only receive water containing medicament. Medical solution is prepared daily in the amount of water calculated for the poultry consumption during 24 hours.
Withdrawal period
Meat: in 12 (calves and pigs) and 11 (poultry) days after the last treatment. Meat received before this time should be disposed or feed to non-productive animals, depending on the conclusion of the veterinarian.
Self life
24 months. Prepared water soluti of the preparati should be used within 24 hours.
Storage conditions
Store in dry, dark places, out of the reach of children, at +5 to +25° С.